Clicking Macrocycles to form Mechanical Bonds

The CuAAC click reaction has been widely used for the preparation of interlocked molecules, such as catenanes and rotaxanes [88]. In the case of rotaxanes, the CuAAC reaction has been used mainly for the synthesis of the axle subsequent threading, clipping, or slipping procedures were utilized to produce the mechanically interlocked product. 

A similar active-template strategy was applied by Goldup etal. forthe formation of doubly interlocked [3]rotaxanes [93]. A photochemical thiol-yne click reaction (a variant of thiol-ene click) was used for the formation of rotaxanes, proceeding mildly at ambient temperature and humidity under an air atmosphere [94]. 

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