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Clearance mechanisms, immunoglobulin

In a study investigating the allometric relationships of pharmacokinetic parameters for five therapeutic proteins, the allometric equations for clearance and volumes of distribution, however, were found to be different for each protein [102]. This variability was attributed to possible species specificity and immune-mediated clearance mechanisms. Species specificity refers to the inherent differences in structure and activity across species. Minute differences in the amino acid sequence may render an agent inactive when administered to foreign species, and may even generate an immunogenic response. Immunogenicity has been clearly demonstrated in a study with the tumor necrosis factor receptor-immunoglobulin fusion protein lenercept. This all-human sequence protein elicits an immune response in laboratory animals which ultimately results in the rapid clearance of the protein [103]. [Pg.37]

Clearance of endogenous and exogenous immunoglobulin takes place via a number of mechanisms. Among these are phagocytosis by mononuclear phagocytic cells (reticuloendothelial clearance), lymphatic clearance, and other tissue-specific and/or specialized mechanisms (discussed in more detail below). [Pg.248]


See other pages where Clearance mechanisms, immunoglobulin is mentioned: [Pg.253]    [Pg.260]    [Pg.95]    [Pg.132]    [Pg.95]    [Pg.2666]    [Pg.2693]    [Pg.1382]    [Pg.1925]    [Pg.60]    [Pg.166]    [Pg.68]   
See also in sourсe #XX -- [ Pg.266 , Pg.267 , Pg.268 , Pg.269 ]




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Immunoglobulin G clearance mechanisms

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