Clausena harmandiana

Coumarins and carbazoles Clausena harmandiana SiOi Hx + AcOEt UV 254 nm Antiplasmoidal activity 86... 

Clausena harmandiana Pierre (root bark) Rutaceae Heptaphylline (54) 2-Hydroxy-3-formyl-7-methoxycarbazole (55) 7-Methoxyheptaphylline (55)... 

The known alkaloid heptaphylline has been isolated from the roots of Clausena harmandiana Pierre (Rutaceae) along with two new carbazole alkaloids identified as 2-hydroxy-3-formyl-7-methoxycarbazole (58) and 7-methoxyheptaphylline (59). The H- and l3C-NMR spectra have been analyzed and used to position the various functional groups (54,55). Other carbazole alkaloids isolated from the roots of Murraya siamensis Craib are identified as murrayanine, girinimbine, and mukonal, which occur together with heptaphylline and compounds 58 and 59 (56-55). Three new alkaloids have also been isolated from M. siamensis and named 3-formyl-2,7-dimethoxycarbazole (60), 3-formyl-2-methoxylcarbazole (O-methylmukonal) (61), and 7-methoxymurrayacine (62) (59). From the roots of Rauwolfia serpentina, the new alkaloid indobine (63) (60), the benzyl ester, and indobinine (64) (61), the cyclohexyl ester of indolepropionic acid, have been isolated and identified. 

Maneerat W, Phakhodee W, Ritthiwigrom T, Cheenpracha S, Promgool T, Yossathera K, et al. Antibacterial carbazole alkaloids from Clausena harmandiana twigs. Fitoterapia 2012 83(6) 1110-4. 

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