Class III drugs: high solubility

Class III — Drug is highly soluble, but poorly permeable... 

Class III Drugs with high solubility and low permeability (e.g. Atenolol)... 

Class III drugs are highly soluble and poorly permeable ... 

BCS Class III High-solubility, low-permeability drugs. Absorption is permeability-rate limited but dissolution will most likely occur very rapidly. For this reason,... 

Cheng, C.L., Yu, L.X., Lee, H.L., Yang, C.Y., Lue, C.S. and Chou, C.H. (2004) Biowaiver extension potential to BCS Class III high solubility-low permeability drugs bridging evidence for metformin immediate-release tablet European Journal of Pharmaceutical Sciences, 22 (4), 297. 

The BCS classes are defined as follows Class I. High Solubility (S) - High Pe Class II. Low S - High Peff Class III. High S - Low P( (T Class IV. Low S - Low Per(. A drug is considered as highly permeable when the extent of absorption is complete in humans, defined by the US FDA as being more than 90%, whereas EMEA requires... 

The drugs listed in the EML were classified according to the criteria explained above. Where no clear classification could be made, the worst case was assumed. For example if a substance is highly soluble, but absolute bioavailability data were not available, the test conditions for BCS Class III substances have been proposed. The same procedure was adopted for fixed combinations, for example amoxicillin and clavulanic acid, the testing procedure was always fixed according to the worst BCS classification, in this example clavulanic acid (BCS Class III/l), because amoxicillin is a BCS Class I drug. This combination would therefore be tested according to BCS Class III requirements. The results of the revised classification can be found in Tables 1-3. 

Class III High solubility, low permeability (i.e. hydrophilic drugs)... 

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