Claisen condensation tetralone

More recent work in this series demonstrated that a carbonyl group can be interposed between the side-chaincarrying aromatic ring and the ethylene function with full retention of activity. Claisen condensation of benzoate with 2-tetralone affords the e-diketone Reaction of... 

The acylation of ketones by ethyl phenylpropynoate is accompanied by cyclization and is a useful route to pyran-4-ones (54JCS1775, 74JHC1101). The base-catalyzed reaction probably proceeds through an alkynic diketone formed by a Claisen condensation. The use of 1-tetralone gives the fused pyran-4-one (413) (59JCS2588). 

To arrive at the 2-aryl-l-tetralone, Zee-Cheng and Cheng (73JHC85, 73JHC867) used the Claisen-Schmidt aldol condensation of veratral-dehyde 30 and acetopiperone 31 to produce (3, 4 -methylenedioxy)-3,4-dimethoxychalcone 32 quantitatively (Scheme 3). On addition of hydrogen cyanide the cyanoketone 33 was formed, which after basic hydrolysis and... 

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