Ketoconazole Citalopram

The effect of ketoconazole on the pharmacokinetics of citalopram has been studied in a double-blind, three-way, crossover trial in 18 men and women (38). The subjects received three treatments with a 14-day washout period a single dose of ketoconazole 200 mg plus placebo, a single dose of citalopram 40 mg plus placebo, and a single dose of ketoconazole 200 mg plus a single dose of citalopram 40 mg. There were no changes in the pharmacokinetics of citalopram after co-admimstration of ketoconazole, suggesting that ketoconazole and other CYP3A4 inhibitors can be safely co-administered with citalopram. 

Gutierrez M, Abramowitz W. Lack of effect of a single dose of ketoconazole on the pharmacokinetics of citalopram. Pharmacotherapy 2001 21(2) 163-8. 

Anorexia developed in a patient taking fluoxetine when itraconazole was started, and it disappeared when the itraconazole was stopped. The pharmacokinetics of citalopram in healthy subjects were not affected by ketoconazole. The clearance of escitalopram was not affected by ketoconazole in an in vitro study. 

Ketanserin (a-adrenoceptor antagonist) Amitryptiline, citalopram, clomipramine, desipramine, doxepin, imipramine, maproptiline, nortriptiline, zimelidine Fluconazole, itraconazole, ketoconazole, micoconazole... 

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