Cirrhosis hyperbilirubinemia

Unconjugated hyperbilirubinemia can result from toxin-induced liver dysfunction such as that caused by chloroform, arsphenamines, carbon tetrachloride, acetaminophen, hepatitis virus, cirrhosis, and Amanita... 

Crixivan 400-mg caps IDV 800 mg + RTV 100 bid IDV 800 mg + RTV 200 mg bid insufficiency due to cirrhosis 600 mg q8hours Take 1 hour before or 2 hours after heavy meals, or concomitantly with low-fat meal No restrictions when used with RTV nausea indirect hyperbilirubinemia hyperlipidemia headache, asthenia, blurred vision, dizziness, rash, metallic taste, thrombocytopenia, alopecia, hemolytic anemia hyperglycemia fat maldistribution increased bleeding episodes in patients with hemophilia (less than RTV)... 

Cataracts in early childhood 1 1 Cataracts often within a few days of birth Vomiting and diarrhea after milk ingestion Jaundice and hyperbilirubinemia Hypoglycemia may be present Liver disease and cirrhosis Lethargy, hypotonia Mental retardation... 

Also. -naphthylisothiocyanate (ANIT) enhances the measured HO activity. ANIT is a drug causing bile stasis, hyperbilirubinemia acutely, bile duct hyperplasia and biliary cirrhosis (Leonard et al. (1981), Ushida et al. (2002)). Therefore its HO activity enhancing potential is well known. 

Liver A 79-year-old man with alcohoUc cirrhosis developed hyperbilirubinemia after taking linezolid 600 mg bd for 5 days for MRS A osteomyelitis [91 ]. Total and direct biUrubin peaked 10 days after drug withdrawal at 340 and 217 pmol/1 respectively and the INR rose to 5.2. Other liver function tests were unchanged from baseline and bilirubin returned to baseline after 2 months. 

Cholongitas E, Georgousaki C, Spyrou S, Dasenaki M. Linezolid-induced severe hyperbilirubinemia in a patient with decompensated cirrhosis. J Infect 2010 60(2) 182-3. 

Liver Severe hyperbilirubinemia developed in a patient with decompensated liver cirrhosis after linezolid therapy for 5 days after linezolid withdrawal the bilirubin continued to rise, but then gradually improved over 10 days [161 ]. 

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