Duloxetine Ciprofloxacin

DULOXETINE ANTIBIOTICS -CIPROFLOXACIN t duloxetine levels with risk of side-effects, e.g. arrhythmias Inhibition of metabolism of duloxetine Avoid co-administration... 

Ciprofloxacin, enoxacin and quinidine are predicted to raise du-ioxetine levels. Duloxetine is predicted to raise the ieveis of fiecai-nide and thioridazine. Due to the theoreticai risk of serotonin syndrome, the manufacturers of duioxetine recommend caution... 

Inhibitors Fluvoxamine , (above), a potent inhibitor of the cytochrome P450 isoenzyme CYP1A2, markedly increases duloxetine levels. The manufaeturers prediet that some quinolones (they name ciprofloxacin and enoxacin) will have the same eifeet and suggest that their eoneurrent use with duloxetine should be avoided. " For a list of elinieally signiiioant CYP1A2 inhibitors, see Table 1.2 , (p.4). 

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