CIpP Protease Activity from Antibiotics to Antivirulence

Modulation of CIpP Protease Activity from Antibiotics to Antivirulence 

In addition, the number of hospital-acquired life-threatening infections has been steadily increasing in the past decades. Thus, great efforts are being undertaken in the search for novel chemical entities with antibacterial activity and possibly novel modes of action. 

How weii protein and iigand interact is reflected by AH and it becomes negative when, for instance, new hydrogen bonding contacts are made. As the absolute temperature T is aiways positive, reactions with a positive change in entropy (or, at most, a smaii negative change) are favored because the second term -FAS - then 

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