Cinnamaldehyde biological activities

Furthermore, substitution of the cinnamaldehyde appeared to have a great effect on the diastereoselectivity of this cascade, from 1.2 1 (2-chloro-6-fluorocinnamaldehyde) to 15 1 (1-naphthylacrolein). This seleetivity also has a great effect on the biological activity, since the desired product induces rearrangements in the cytoskeleton to form more polarized cells, which initiates maturation while the spiroisomeric product impairs neural development. 

TRPAl has generated considerable excitement because of its restricted expression and unique biology. In particular, TRPAl has been identified as a neuronal sensor of multiple respiratory irritants, including acrolein, cinnamaldehyde, and allyl isothiocyanate (AITC), the active ingredient in mustard oil (Bandell et al. 2004 Jordt et al. 2004). 

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