Cinchona Alkaloids in Asymmetric Transformations

This section focuses on the role of cinchona alkaloids as Br0nsted bases in organocatalytic asymmetric reachons. Cinchona alkaloids may act in a Lewis basic manner when the quinucHdine nitrogen initiates a nucleophilic attack to the substrate in asymmetric reactions such as the Baylis-Hillman, asymmetric a-halogenation, and alkylation [9]. 

The reactions discussed here highlight the utility of the catalyst, notably the design of the scaffold to achieve the desired stereoinduction with low catalyst loading while achieving high yields. These reactions are categorized as conjugate additions to enones or enoates, imines, azodicarboxylates, and nitroolefins. 

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