Mirtazapine Cimetidine

CIMETIDINE MIRTAZAPINE t efficacy and adverse effects of mirtazapine Inhibition of metabolism via CYP1A2, CYP2D6 and CYP3A4 Consider alternative acid suppression, e.g. H2 antagonist (proton pump inhibitors will interad in poor CYP2D6 metabolizers) or monitor more closely for side-effects 1 dose as necessary... 

D6 Tricyclic antidepressants (TCAs), benztropine, perphenazine, clozapine, haloperidol, codeine/oxycodone, risperidone, class Ic antiarrhythmics, 3 blockers, trazodone, paroxetine, maprotiline, amoxapine, duloxetine, mirtazapine (partly), venlafaxine, bupropion Fluoxetine, paroxetine, duloxetine, hydroxybupropion, methadone, cimetidine, haloperidol, quinidine, ritonavir Phenobarbital, rifampin... 

Sitsen JM, Maris FA, Timmcr CJ Concomitant use of mirtazapine and cimetidine A drug-drug interac-... 

Quetiapine dose not appear to interact to a clinically relevant extent with cimetidine, fluoxetine, imipramine or lorazepam. Isolated cases of adverse outcomes have been reported with diphenhydramine, iovastatin and mirtazapine. 

In a double-blind, crossover study in 12 healthy subjects, placebo or cimetidine 800 mg twice daily were given for 14 days. Mirtazapine 30 mg was given at night on days 6 to 12. Concurrent administration of cimetidine with mirtazapine increased the AUC and peak plasma levels of mirtazapine by 54% and 22%, respectively. Trough and average mirtazapine plasma levels, at steady state, were increased by 61% and 54%, respectively,... 

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