Hypericin Cimetidine

Johne A, Perloff ES, Bauer S, Schmider J, Mai I, Brockmoller J, Roots I. Impact of c3dochrome P-450 inhibition by cimetidine and induction by carbamazepine on die kinetics of hypericin and pseudohypericin in healthy volunteers. EurJ Clin Pharmacol (2004) 60, 617-22. 

Cimetidine does not significantly alter the metabolism of the constituents of St John s wort, hypericin and pseudohypericin. 

A placebo-controlled study in healthy subjects taking St John s wort (LI160, Lichtwer Pharma) 300 mg three times daily found that, apart from a modest 25% increase in the AUC of pseudohypericin, cimetidine 1 g daily (in divided doses) did not significantly affect the pharmacokinetics of either the hypericin or pseudohypericin constituents of St John s wort. The available evidence therefore suggests that cimetidine is unlikely to affect the dose requirements of St John s wort. ... 

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See also in sourсe #XX -- [ ]

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