Gabapentin Cimetidine

CjHf,N2 1467-79-4) see Azapropazone dimethyl cyanocarboimidodithioatc (C4HSN2S2 10191-60-3) see Cimetidine dimethyl cyclohexylidenemainnate (C11H14O4 94286-34-7) see Gabapentin (S )-2,2-dimethylcyclopropanecarboxamide (QH iNO 75885-58-4) see Cilastatin... 

Drugs that may affect gabapentin include antacids, cimetidine, hydrocodone, and morphine. Drugs that may be affected by gabapentin include oral contraceptives and hydrocodone. 

Gabapentin. This agent is used as an adjunctive agent and is relatively safe from side effects in nonpregnant adult patients. There was noted a small decrease in gabapentin excretion with concurrent cimetidine administration, which was not clinically significant. It is recommended that gabapentin be taken at least 2 h after antacid administration. 

A brief report notes that cimetidine decreased the renal clearance of gabapentin by 12%, which was not expected to be clinically important. No study details were given. ... 

Lai R, Sukbuntherng J, Luo W, Vicente V, Blumenthal R, Ho J, Cundy KC. Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol 2010 69(5) 498-507. 

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