Dolasetron Cimetidine

Cimetidine had no important effect on dolasetron or granisetron pharmacokinetics. 

A study in 18 healthy subjects given dolasetron 200 mg daily found that cimetidine 300 mg four times daily for 7 days increased the AUC and maximum plasma level of the active metabolite of dolasetron, hydrodola-setron, by 24% and 15%, respectively, probably due to the inhibitory effect of cimetidine on the cytochrome P450-mediated metabolism of dolasetron. As 400-mg oral doses of dolasetron have been shown to be well tolerated (the usual oral dose is up to 200 mg) these ehanges were not considered to be clinically significant. Therefore no special precautions appear necessary if cimetidine and dolasetron are used eoneurrently. 

DimmittDC, Cramer MB, Keung A, Arumugham T, Weir SJ. Pharmacokinetics of dolasetron with coadministration of cimetidine or rifampin in healthy subjects. Cancer Chemother Pharmacol ( 999) 43, 126-32. 

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