Cignolin

Runne, U., Anthralin-salicylic acid therapy of psoriasis. Cignolin-salicylic acid-vaseline treatment and Lasan paste in a right-left comparison. Hautarzt, 1974, 25 199-200. 

Muller R, Naumann E, Detmar M, Orfanos CE. Stabilitat von Cignolin (Dithranol) in teerhaltigen Salben mit und ohne Salicylsaurezusatz. Oxidation in Danthron und Dithranoldimer. [Stability of cignolin (dithranol) in ointments containing tar with and without the addition of salicylic acid. Oxidation to danthron and dithranol dimer.] Hautarzt 1987 38(2) 107-11. 

Dithranol (anthralin, cignolin) is a mandatory irritant in psoriasis therapy. Staining of clothes, skin, nails, and hair are frequent and should be explained to patients. An unusual cutaneous anthralin-like staining of the perineum may follow use of danthrone, as a laxative. Danthrone (1,8-dihydroxyanthroquinone) is closely related to dithranol (1,8,9-anthracenetriol). Contact allergy has not been reported. 

The plant excretion chrysarobin is a mixture of various anthracene derivatives and can be chromatographed Just like the synthetic 1,8-dihydroxyanthranol (cignolin, anthralin, dithranol) on silica gel G layers with solvent XII it may be detected in this way in the corresponding preparations [14]. 

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