Fluconazole Cidofovir

Items 6-7 A patient with AIDS has a CD4 count of 45/ xL. He is being maintained on a three-drug regimen of indinavir, zalcitabine, and zidovudine. For prophylaxis against opportunistic infections, he is also receiving cidofovir, fluconazole, rifabutin, and trimethoprim-sulfamethoxazole. 

In a study, 6 HTV-positive subjects were given fluconazole 100 mg daily for 13 days with a single 3-mg/kg dose of cidofovir with probenecid given on day 13. The pharmacokinetics of both drugs were unaffected. ... 

Cidofovir with probenecid modestly decreased levels of trimethoprim and sulfamethoxazole (co-trimoxazole), and caused moderate increases in didanosine levels, but did not alter fluconazole pharmacokinetics. None of these drugs altered cidofovir pharmacokinetics. 

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