CIC Employed in the Passerini Reaction

SCHEME 7.101 Application of CIC Izk in the synthesis of pyrrolodiazepinedione 334. 7.2.5 CIC Employed in the Passerini Reaction 

2 Tert-Butyl Isocyanide Recently, Ganem and coworkers have reported the first application of CIC in the original P-3CR. They have employed NaN02 (Method A) and N2O4 (Method B) to convert TBIC (Izb) derived secondary amide of the P-3CR product 349 into carboxylic acid derivatives 350 without affecting the existing 

3 4-Isocyanopermethylbutane-l,l,3-triol More recently, Filho and coworkers have utilized the CIC IPBT (Ize) in the P-3CR and employed milder 

SCHEME 7.105 Mechanism of formation of acid-ester from the CIC Izd-derived Passerini 

CH2CI2 K7 b) DOWEX-500 cation MeOH exchange resin 

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