Chronic progressive nephropathy incidence

Chronic inhalation exposure to 0, 75, 250 or 750 ppm [0, 0.32, 1.1 or 3.3 g/m ] ethylbenzene for 6 h per day on five days per week for 104 weeks caused an increased incidence of renal tubule h erplasia in male Fischer 344/N rats and increased severity of spontaneous, age-related chronic progressive nephropathy in males and females. Male B6C3Fi mice developed an increased incidence of alveolar epithelial metaplasia, syncytial alterations of hepatocytes, hepatocellular hypertrophy, hepatocyte necrosis and thyroid gland follicular-cell h erplasia. Exposure to ethylbenzene also caused an... 

CHEMICALS INCREASING THE INCIDENCE OF RENAL TUMORS THROUGH EXACERBATION OF SPONTANEOUS CHRONIC PROGRESSIVE NEPHROPATHY (CPN)... 

Seely, J. C., Haseman, J. K., Nyska, A., Wolf, D. C., Everitt, J. I., and Hailey, J. R. (2002). The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats. Toxicol Pathol 30, 681-686. 

Study reduced the incidence of these tumours so it was barely significant. The available data strongly support the hypothesis that the mode action is dependent on a2u- globulin nephropathy and exacerbation of chronic progressive nephropathy, both of which are considered of no human relevance. 

As noted previously, available therapies moderate the hyperglycemia of diabetes, but fail to completely normalize metabolism. The long-stand-hg elevation of blood glucose causes the chronic complications of diabetes—premature atherosclerosis, retinopathy, nephropathy, and neuropathy. Intensive treatment with insulin (see p. 339) delays the onset and slows the progression of these long-term complications. For example, the incidence of retinopathy decreases as control of blood glu-... 

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