Chromium, allylic 1,2-asymmetric induction

Allylic Chromium Reagents 12-Asymmetric Induction fAnti/Syn Control)... 

Maguire, R. J., Mulzer, J., Bats, J. W. 1,4-Asymmetric Induction in the Chromium(ll)-and Indium-Mediated Coupling of Allyl Bromides to Aldehydes. J. Org. Chem. 1996, 61, 6936-6940. 

Asymmetric induction at an allylic centre in the side-chain of a phenolic ether in the form of its chromium tricarbonyl complex has been described. The chiral... 

In the 15 years since Fiirstner et al. developed the first NHK reaction using catalytic quantities of chromium, the subsequent stereoselective, catalytic variant has become a valuable tool in catalytic asymmetric synthesis. Many studies on the NHK reaction have focused on the application of ligands that have proven successful in a range of other catalytic asymmetric processes. For example, the salen- and oxazoline-derived ligands that have been applied have advanced the scope of the NHK reaction in terms of reactivity and asymmetric induction in a wide array of carbon-carbon forming processes. These processes now include allylation, crotylation, vinylation, methallylation, aUenylation, homoallenylation, and propargylation. Xia and Yamamoto s TBOxCr(III)Cl complex has afforded some of the highest levels of enantioselectivity in a series of allylation, crotylation, aUenylation, and more recent dienylation and alkynylation studies. 

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