Chromatin positive staining

Figure 20.1 shows a cerebral tumor from the lumbosacral region of a middle-aged woman. The H E-stained slide reveals a neoplasm with mainly epithelioid cells and a few clear cells, and abundant round to oval nuclei with fine chromatin (Table 20.6 see Fig. 20.lA). Its IHC is focally positive to epithelial membrane antigen (EMA) (see Fig. 20.IB). Boxes 20.1 and 20.2 show carcinoma, chordoma, craniopharyngioma, pituitary adenoma, and meningioma to be EMA positive. This tumor is negative for cytokeratin (CK) CAM5.2 (see Fig. 20.1C), so it does not fit the immunohistochemical...

Fig. 11 Quantitative measures of lamin-chromatin separation distances in Drosophila early embryo nuclei, (a) Probability of lamin-chromatin separation distance as a function of difference in circumferential solid angle along the nuclear periphery (AS) and difference in radial position (Ar) (see Paddy et al., 1990, for more details). (A0, Ar) = (0, 0) represents the center of the nearest local maximum in the lamin staining pattern. The distance above the A0, Ar plane is proportional to the probability that one of the 93 peripheral chromatin loci is located A0, Ar from the nearest local maximum in the antilamin staining pattern. The maximum value in the plot represents a probability of 4%. (b) Probability of lamin-chromatin separation distance as a function of difference in circumferential solid angle (A0). This plot results from integrating the data in panel a along the radial (Ar) axis, (c) probability of lamin-chromatin separation distance as a function of total separation distance. This plot results from using the Ad, Ar) coordinates of each point in panel a to calculate the separation distance at which the observed probabilities occur. [Reprinted with permission from Paddy el al. (1990). Copyright Cell Press.]...

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