Chou-Fasman rules for

The existence of a Pro residue in the pyrokinins raises the possibility of the presence of a turn structure in the active core region. Indeed, a fi-turn is predicted by Chou-Fasman ( ) rules for the sequence Thr-Pro-Arg-Leu within the active core. The significant activity of the cyclic LPK analog cvclo-FAsn-Thr-Ser-Phe-Thr-Pro-Arg-Leu] (Figure 6), in which the N- and C-termini are linked by an amide bond, is consistent with the presence of a )8-turn. This cyclic analog demonstrated a threshold concentration value of 3.5 x 10 M or a significant 4% of its linear counterpart. 

The Chou-Fasman rules for predicting secondary structure of a region of a polypeptide sequence are the following ... 

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