Digitoxin cholestyramine

The principal precaution with use of the bile acid resins is the possibility of impaired absorption of other drugs given orally at the same time. Cholestyramine and colestipol can bind many other drugs, such as digitoxin, phenobarbital, chlorothiazide, and warfarin, and delay or prevent their absorption. For this reason, other drugs should always be taken at least 1 hour before or 4 to 6 hours after the resin. The resins can also decease absorption of fat-soluble vitamins. 

Kuhlmann J. Use of cholestyramine in three patients with beta-acetyldigoxin, beta-methyldigoxin and digitoxin intoxication. Int J Clin Pharmacol Ther Toxicol 1984 22(10) 543-8. 

Hantson P, Vandenplas O, Mahieu P, Wallemacq P, Hassoun A. Repeated doses of activated charcoal and cholestyramine for digitoxin overdose pharmacokinetic data and urinary elimination. J Toxicol Clin Exp 1991 ll(7-8) 401-5. 

Carruthers SG, Dujovne CA. Cholestyramine and spironolactone and their combination in digitoxin elimination. Clin Pharmacol Ther 1980 27(2) 184-7. 

CA inhibitors acetazolamide Inotropes digoxin, digitoxin Resins cholestyramine, colestipol... 

Caldwell JH, Bush CA, Greenberger NJ. Interruption of the enterohepatic circulation of digitoxin by cholestyramine./CIi 7nvesr(1971) 50, 2638-44. 

Pabst J, Leopold G, Schad W, Meub R. Bioavailability of digitoxin during chronic administration and influence of food and cholestyramine on the bioavailability after a single dose. Naunyn Schmiedehergs Arch Pharmacol (1979) 307, R70. 

Qvigstad, T. and Skare, S. (1974) Digitoxin intoxication Treatment with the steroid binding resin cholestyramine (in Norwegian). T. Norske Laegeforen, 94, 1190. 

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