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Cholesterol with biomembranes, surface

Correlation of Surface Properties of Cholesterol with Biomembranes. [Pg.213]

Various types of molecular interactions which occur in mixed mono-layers can be distinguished by simultaneous measurements of the surface pressure, potential, and fluidity of monolayers. Limitations of Goodrich s thermodynamic treatment of mixed monolayers are mentioned. Surface properties of cholesterol have been correlated with its function in biomembranes. [Pg.214]

Phospholipids and glycosphingolipids are amphipathic lipid constituents of membranes (Chapter 10). They play an essential role in the synthesis of plasma lipoproteins (Chapter 20) and eicosanoids (Chapter 18). They function in transduction of messages from cell surface receptors to second messengers that control cellular processes (Chapter 30) and as surfactants. Cholesterol is mainly of animal origin and is an essential constituent of biomembranes (Chapter 10). In plasma, cholesterol is associated with lipoproteins (Chapter 20). Cholesterol is a precursor of bile acids formed in the liver of steroid hormones secreted by adrenals, gonads, and placenta and 7-dehydrocholesterol of vitamin D formed in the skin. In tissues, cholesterol exists primarily in the unesterified form (e.g., brain and erythrocytes), although appreciable quantities are esterified with fatty acids in liver, skin, adrenal cortex, and plasma lipoproteins. [Pg.401]

Other experiments carried out with sarcoplasmic reticulum membranes gave results that do not support the idea that cholesterol is excluded by a lipid annulus. This work showed that as the cholesterol content of the biomembrane was raised, the enzyme activity decreased [77,78]. Spin-labelled cholesterol has also been used to study this problem with the conclusion that cholesterol does contact the surface of the protein, but with a lower probabihty than does the lipid [79]. [Pg.160]


See other pages where Cholesterol with biomembranes, surface is mentioned: [Pg.4]    [Pg.13]    [Pg.153]    [Pg.154]    [Pg.489]   


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