Cholesterol Reference Method Laboratory Network

Fig. 2 Results of manufacturer comparisons for total cholesterol performed from January 2000 through March 2003. Sixteen manufacturers performed 79 comparisons. Bias versus the Cholesterol Reference Method Laboratory Network (CRMLN) laboratory is plotted on the a-ax is and the coefficient of variation (CV) (%) is plotted on the y-axis. Vertical lines at -3% and +3% bias and the horizontal line at 3% CV indicate the National Cholesterol Education Program recommendations for accuracy and precision for clinical laboratories...

Kimberly MM, Leary ET, Cole TG, Waymack PP. Selection, validation, standardization, and performance of a designated comparison method for HDL-cholesterol for use in the cholesterol reference method laboratory network. Clin Chem 1999 45 1803-12. 

Table 1 Metrological properties of methods used by the Choles- CV coefficient of variation, HDLC high-density lipoprotein cho-terol Reference Method Laboratory Network (CKMLN). 2 KM lesterol, SD standard deviation, LDLC low-density lipoprotein Secondary reference method, DCM designated comparison meth- cholesterol, NA not available od, IDMS isotope dilution mass spectroscopy, AK Abell-Kendall,...

Myers GL, Kimberly MM, Waymack PP, Smith SJ, Cooper GR, Sampson EJ. A reference method laboratory network for cholesterol a model for standardization and improvement of clinical laboratory measurements. Clin Chem 2000 46 1762-72. 

Table 2 Comparison of Cholesterol Reference Method Laborato- tute, NIST National Institute of Standards and Technology (US ry Network (CRMLN) traceability model to the International Or- NMI), IDMS isotope dilution mass spectrometry, ACL accredited ganization for Standardization (ISO) model. BIPM International calibration laboratory, AK Abell-Kendall Bureau of Weights and Measures, NMI National Metrology Insti-...

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