Cholesterol interaction with filipin

The macrolide antibiotic filipin interacts with 3-p-hydroxysterols such as cholesterol in the plasma membrane to form filipin-sterol complexes (59). Subsequently, the filamentous caveolin-l-coat rapidly disassembles, which... 

The stoichiometry of the polyene antibiotic—cholesterol interaction has been measured in various systems with different techniques. The filipin—cholesterol interaction has been the subject of extensive study and the results suggest this interaction is equimolar. The data on other polyenes is not so definite, but suggests that only a small number of sterol molecules interact with one polyene antibiotic molecule. 

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