Cholesterol, esterification, in liver

Simon, J. B., and Scheig, R., Serum cholesterol esterification in liver disease. Importance of lecithin-cholesterol acyltransferase. New Engl. J. Med. 283,841-846 (1970). 

Cholesterol esterification in liver (Goodman et al., 1964 Erickson and Cooper, 1980) as well as in many other types of tissues (see Spector et al., 1979 Erickson and Cooper, 1980, for references) is catalyzed by the enzyme acyl-CoA cholester-ol acyltransferase (EC 2.3.1.26 ACAT), which reacts free cholesterol with a fatty acyl-CoA to form cholesteryl ester. This membrane-bound enzyme is found mainly in liver microsomes and has been partially characterized. 

---