Cholestasis coagulopathy

An elevation of AT III activity (> 120%) is found in cholestasis and obstructive jaundice. This leads to hypo-coagulopathy with the danger of bleeding, (s. tab. 5.13)... 

A fish oil-based intravenous lipid emulsion in the treatment of liver disease associated with parenteral nutrition has been compared with soybean oil in an open study in 42 infants with short bowel syndrome who developed cholestasis [35 ]. There were three deaths and one liver transplantation in those who received the fish oil, compared with 12 deaths and 6 transplants in those who received soybean oil The fish oil was not associated with hypertriglyceridemia, coagulopathy, or deficiency of essential fatty acids. 

Extrahepatic biliary obstruction occurs due to a myriad of benign and malignant etiologies. The resulting cholestasis may lead to malabsorption, coagulopathy, pruritus, hepatocellular failure, renal dysfunction. 

---