Cholestane saponins

Saponins Steroid alkaloids Cholestane Conessine Cyclopamine Jervine Pregnenolone Protoveratrine A Protoveratrine B Solanidine Solasodine Squal amine Tomatidine... [Pg.10]

Plant saponins are not normally considered to be promising anticancer lead compounds, partly because of problems with general toxicity. One exception to this rule is the acylated cholestane diglycoside OSW-1 (31), which was isolated from the bulbs of Omithogalum saundersiaehj Sashida and coworkers in 1992. In addition to OSW-1 three related compounds were also isolated and two were tested for inhibitory activity on cyclic AMP phosphodiesterase. OSW-1 and the related compound 32 were the most active, with IC50 values of 55 and 5 pmoir, respectively. ... [Pg.13]

Spirostana the oxygen-containing parent structure of the steroid saponins (see Saponins). The S. system is formally derived from the parent hydrocarbon cholestane (see Steroids). The name S, embraces the configuration of all asymmetric centers with the exception of positions 5 and 25. [Pg.634]

Cholestane glycosides furostanol open-chain steroidal glycosides spirostanol stereochemistry steroidal saponins structure elucidation... [Pg.3226]

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