Chlorpyrifos relative inhibitory potency

FIGURE 57.8. Spectrum of log values of relative inhibitory potency (RIP) = 7i(AChE)/ i(NTE), where = himolecular rate constant of inhibition. As log(RIP) becomes more positive, cholinergic potential increases as log(RIP) becomes more negative, delayed neuropathic potential increases. CPMO-chlorpyrifos methyl oxon. DCV derivatives refer to symmetrical dialkyl-2,2-dichlorovinyl phosphate (dichlorvos) compounds. EOPF - ethyl n-octylphosphonofluoridate. Data from Kropp and Richardson (2003) Richardson (1992) and Wu and Casida (1996). 

Kropp, T.J., Richardson, R.J. (2003). Relative inhibitory potencies of chlorpyrifos oxon, chlorpyrifos methyl oxon, and mipafox for acetylcholinesterase versus neuropathy target esterase. J. Toxicol. Environ. Health Part A 66 1145-57. 

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