Chlorpromazine surface activity

Many drugs are surface active, e.g. chlorpromazine, diphenylmethane derivatives (such as diphenhydramine) and tricyclic antidepressants (such as amitriptyline) [14]. As an illustration is the structure of chlorpromazine (13.3). 

Uptake of paraquat by rat lung slices was found to be inhibited by chlorpromazine and efflux of paraquat from the slices was enhanced by the drug in vitro. However, in vivo chlorpromazine potentiated the toxicity of paraquat rather than reducing it as expected [187]. The metabolism of CPZ in vivo may account for the unexpected findings, although the decreased surface activity of some of the metabolites might be expected to give rise to a decreased membrane interaction. The increased toxicity was ascribed to reduced urinary excretion of paraquat and its increased pulmonary levels in the presence of CPZ, by mechanisms as yet not understood. 

Chloropentammine Ir (HI) complex, incomplete Ir (III) autoreduction, 39 151-152 Chloroplasts, quantum conversion in, 14 1 1 -Chloroprop-2-ene thermal decomposition, 41 80 Chlorpromazine, reactivity with EDA complexes, 20 333, 336 CH O, 32 374-375 CH3OH, oxidation, 38 21-23 Cholestenone, hydrogenation, 25 57, 58 Cholesterol, biosynthesis of, 25 382 Cholinesterases, stracture of active surface, 10 130... 

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