Chlorpromazine studies/trials

There has been one comprehensive meta-analysis including over 80 studies and over 30 000 patients (814). A meta-analysis of trials of neuroleptic drugs showed the following mean weight gains in kg after 10 weeks of treatment clozapine, 4.5 olanzapine, 4.2 thioridazine, 3.2 sertindole, 2.9 chlorpromazine, 2.6 risperidone, 2.1 haloperidol, 1.1 fluphenazine, 0.43 ziprasidone 0.04 molindone, —0.39 placebo, —0.74... 

A large NIMH study comparing imipramine, chlorpromazine and placebo, which was conducted in the United States with a total of 714 subjects, was also essentially negative. The study involved at least 97 different outcomes measured at each of the seven weeks of the trial, yielding a total of almost 700 measures. The paper, which describes the main results, contains no data from any of the scales used, and only presents qualitative impressions of treatment response, which are difficult to interpret. This analysis also excluded 159 black patients who showed a poorer response to imipramine. The paper still only concluded that although imipramine did have beneficial effects these effects were generally small (Raskin et al. 1970). In subsequent publications, results for a few selected items on the scales are given at points... 

A meta-analysis of placebo-controlled trials with chlorpromazine showed it was better than placebo in all 26 studies at doses over 400-500 mg per day. 

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