Chlorpromazine cholesterol

Chemically modified electrodes, 39, 118 Chemometrics, 197 Chemoreceptor, 187 Chip, 194, 195 Chloramphenicol, 70 Chloride electrode, 159 Chlorpromazine, 34 Cholesterol, 182 Cholinesterase, 182 Chromium, 85, 86 Chronoahsorptometry, 42 Chronoamperometry, 21, 60, 130, 135, 132, 177... 

Chloropentammine Ir (HI) complex, incomplete Ir (III) autoreduction, 39 151-152 Chloroplasts, quantum conversion in, 14 1 1 -Chloroprop-2-ene thermal decomposition, 41 80 Chlorpromazine, reactivity with EDA complexes, 20 333, 336 CH O, 32 374-375 CH3OH, oxidation, 38 21-23 Cholestenone, hydrogenation, 25 57, 58 Cholesterol, biosynthesis of, 25 382 Cholinesterases, stracture of active surface, 10 130... 

Figure 4. Permeability of a phospholipid/cholesterol film for different solutes ascorbic acid (1), tyrosine (2), uric acid (3), acetaminophen (4), cysteine (5), desipramine (6), perphenazine (7), trimipramine (8), promethazine (9), and chlorpromazine (10). (Adapted from ref. 13.)...

Chlorpromazine can cause overestimation of cholesterol (Zlatkis-Zak reaction) (26). 

However, foUowing enrichment of the cells with exogenous cholesterol or incubation with 0.1 mM chlorpromazine [156], the whole of the cholesterol pool becomes available to the cholesterol oxidase. This means that the time-course of cholesterol oxidation can be determined and hence the rate of flip-flop. Based on such studies, a half-time of less than 3 sec at 37°C has been found for transposition of cholesterol across the bilayers [157]. These studies have also been extended to probe features of lipid-cholesterol organisation in the human erythrocyte membrane [158]. Clearly, such studies are relevant to our understanding of the mechanisms of cholesterol loss from cells in vivo by the methods outhned earlier. 

Gross et dl. (1960) examined the effect of various concentrations of chlorpromazine on cholesterol biosynthesis in the brain of 10-day-old rats. High concentrations of the drug (10 M) blocked the in vitro incorporation of l-C -acetate, G-C -glucose, and 2-C -mevalonate into brain cholesterol. Smaller doses of chlorpromazine appeared to stimulate... 

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