Chlorotoluenes, transformation

The results for the hydrolysis of chlorobenzene, o-chlorotoluene and p-chloroanisole in presence of cuprous oxide at different temperatures (Fig. 14) show a good selectivity for the reaction of the chlorobenzene. But, the p-chloroanisole is also transformed by a secondary demethylation reaction into the corresponding p-chlorophenolate. 

Yang and Her [ 193] have described a rapid method for the determination of down to 200 ppt of semi-volatile compounds such as 1-chloronaphthalene, nitrobenzene and 2-chlorotoluene in soils by coupling solid-phase microextraction with attenuated total reflectance Fourier transform infrared spectroscopy. 

Toluene-4-sulfonic acid is used as a starting material in the production of 2-chloro-5-aminotoluene-4-sulfonic add (CLT-acid). CLT-acid is manufactured by chlorination of toluene-4-sulfonic add, transformation of 2-chlorotoluene-4-sulfonic add into 2-chloro-5-nitrotoluene-4-sulfonic acid followed by the reduction of the nitro group with iron/HCl. CLT-acid is used, for example, as a raw material in the production of Pigment Red 52 1, Pigment Red 53 1 and other metal complexes. 

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