76-15-3 1-Chloropentafluoroethane

Chloropentafluoroethane Neoprene or chloroprene Silver, brass, aluminium, steel. 

Chloronaphthalene 40 Chloronitrobenzenes, 40 Chloropentafluoroethane, 40 Chlorophacinone, 40 4-Chloro-o-phenylenediamine, 40 Chlorophenols, 40 Chlorophenols, Mono, 40 Chloropicrin, 40 Chloroplatinic acid, 41 Chloroprene, 41... 

Although antimony pentafluonde can fluorinate l,l,2-tnchloro-l,2,2-trifluo-roethane to chloropentafluoroethane, this route is not used industnally because antimony pentafluonde and hydrogen fluoride are too corrosive. Both dichloro-tetrafluoroethane and chloropentafluoroethane are produced by vapor-phase fluor-ination of tetrachloroethene with proprietary chromia catalysts at 300 to 500 °C (equation 1). 

By varying the temperature and the ratio of hydrogen fluonde to tetrachloroethene, the ratio of chloropentafluoroethane to dichlorotetrafluoroethanes can be varied at will The ratio of 1,2-dichlorotetrafluoroethane to 1,1-dichlorotetra-fluorocthane depends upon the temperature of the catalyst, higher temperatures favoring the latter, with yields that can vary from 10 to 50% depending upon operating condidons. 

Chloro-4-nitrobenzene 1 -Chloro-1 -nitropropane Chloropentafluoroethane Chloropicrin(<> fl-Chloroprene"1 ... 

This reagent, prepared in situ from butyllithium and chloropentafluoroethane as an ether solution, has several times decomposed violently on addition of a few drops of a chlorophosphine. This is attributed to running the preparation too cool (< —90°C), so that it had not proceeded. However ... 

Toxicology. Chloropentafluoroethane has low inhalation toxicity and little potential for cardiac sensitization. 

Inhalation studies with chloropentafluoroethane in anesthetized dogs, rats, and monkeys showed that exposure to 100,000-2 5 0,000 ppm, under certain conditions, caused an increase in blood pressure, accelerated heart rate, depression of myocardial contractility and sensitized the heart to epinephrine.Compared with other chlorofluorocarbons, it is ranked among the least potent for cardiac sensitization." ... 

In a NIOSH Health Hazard Evaluation of refrigeration workers exposed far below the threshold limit values (TLVs) for chloropentafluoroethane and chlorodifluoromethane, 27 workers were medically evaluated. Seventy-one percent complained of dizziness and lightheadedness compared with twenty-one percent of controls. Palpitations were reported in 36% of exposed and none of the non-exposed workers. No clinical neurological or electroneurophysiological abnormalities were detected in eight of the refrigeration repair workers followed for 3 years during continuous employment. ... 

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