Chloroform Ciprofibrate

Chloro-2-fluoro-5-sulfamoyl benzo-nitrile Azosemide Chloroform Ciprofibrate Fenofibrate Heparin Orgotein... 

Ciprofibrate (48), a more potent lipid-lowering agent clofibrate, is prepared from Simmons-Smith product by Sandmeyer replacement of the amino group by a hydroxyl via the diazonium salt. Phenol undergoes the Reimer-Thiemann like process common to these agents upon alkaline treatment with acetone and chloroform to complete the synthesis of ci profib-rate (48). 

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