Chloroamination Chloroformate

The amino alcohols described above are readily converted into the corresponding chloroamines by reaction with phosphorus penta-chloride 522 or thionyl chloride 144,292,298> 336,491,523,622 in chloroform. 

It has been demonstrated that when uracils are iodinated with electrophilic iodine (using chloroamine-T and iodide or Iodo-Gen) in aqueous solution, or NIS in ethanol or chloroform-ethanol, addition products (47 or 48) form initially, eliminating water or ethanol when heated (81RTC267) (Scheme 41). 

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