Chloroacetyl fluoride

Chloroacetic acid, reaction with salicyl-aldehyde, 46, 28 Chloroacetone, 46, 3 Chloroacetyl fluoride, 45, 6 o-Chloroacetyl isocyanate, 46,16 -Chloroaniline, reaction with carbon disulfide and aqueous ammonia,... 

It is interesting to compare the toxicity of fluoroacetyl chloride with the isomeric chloroacetyl fluoride. The former possessed a toxicity comparable to that of methyl fluoroacetate, whereas the latter was relatively non-toxic. This is readily understandable in that fluoroacetyl chloride gives the toxic fluoroacetic acid, whereas chloroacetyl fluoride hydrolyses to chloroacetic acid and the relatively non-toxic (at the concentrations employed) hydrogen fluoride. Fluoroacetyl fluoride also possessed a toxicity comparable with that of fluoroacetyl chloride or of methyl fluoroacetate, again showing that the COF group contributed practically nothing. Acetyl fluoride was also non-toxic. 

CH2F CH2 N-ftjX, chlorofluoroethane sulphur-containing compounds, e.g. CH2F CH2 Si2 esters of 1-alkylated fluoroacetic acids, CH-ft F C02iZ and CiZ iZ F C02B acetyl and chloroacetyl fluoride. 

These stable, crystalline salts are prepared by the reaction of chloroacetyl fluoride and bromoacetyl fluoride with antimony pentafluoride in liquid SO2 or FCI2C-CCIF2 (Freon 113). 

Chloianil, 168,667,674 p-Chloianil, 168 Chloieal, 605 Chlorination, 23, 562 Chlorine, 101-102 Chlorine bromide, 102 Chloroacetaldehyde, 267 Chloroacetonitrile, 102-103 Chloroacetyl fluoride, 103 Chloroacetyl isocyanate, 634 Chloroacetylium hexafluorantimonate,... 

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