7-Chloro-4-quinolinol

C. 7-Chloro-4-quinolinol and 4,7-dichloroquinoUne. The above air-dried acid (Note 7) is suspended in 1 1. of Dowtherm A in a 2-1. flask equipped with a stirrer and a reflux condenser. The mixture is boiled for 1 hour under a stream of nitrogen to assist in the removal of the water (Note 8). The clear, light-brown solution is cooled to room temperature, and 90 ml. (150 g., 0.98 mole) of phosphorus oxychloride is added. The temperature is raised to 135-140°, and the mixture is stirred for 1 hour. The reaction mixture is cooled and poured into a separatory funnel. The portion of the mixture adhering to the flask is rinsed into... 

If the 7-chloro-4-quinolinol is desired, it is more convenient to effect the decarboxylation without a solvent. ... 

Certain halogen derivatives of 8-hydroxyquinoline have a record of therapeutic efficacy in the treatment of cutaneous fungus infections and also of amebic dysentery. Among these are 5-chloro-7-iodo-8-quinolinol [130-26-7] (iodochlorhydroxyquin, Vioform), 5,7-diiodo-8-hydroxyquinoline [83-73-8] (diiodohydroxyquin), and sodium 7-iodo-8-hydroxyquinoline-5-sulfonate [885-04-1] (chiniofon) (196—198). 

Halquinol is a mixture of compounds obtained by the chlorination of 8-quinolinol (Fig. 6.4). It is composed of 5,7-dichloro-8-quinolinol (57-74%), 5-chloro-8-quinolinol (23-40%), and 7-chloro-8-quinolinol (up to 3%). Halquinol is active against both gram-positive and gram-negative bacteria, fungi, and protozoa. 

After eliminating of free iodine by addition of sodium thiosulfate the obtained precipitate was washed with water. To residue 1% solution of acidum hydrochloricum (50.0 kg) and rapidly was heated to 50°C. Then it was washed with water and dried, so 5-chloro-7-iodo-quinolinol-8 was obtained, melting point 170°-175°C. 

Chemical Name 8-Quinolinol, 5,7-dichloro-, mixt. with 5-chloro-8-quinolinol and 7-chloro-8-quinolinol... 

Quinolinol (mixture of 57-74% 5,7-dichloro-8-hydroxyquinoline, 23-40% 5-chloro-8-hydroxyquinoline and less than 3% 7-chloro-8-hydroxyquinoline) was synthesized by interaction of 8-hydroxyquinoline with sulfuryl chloride in glacial acetic acid at 50°C for 1.5 hours. The reaction mixture was cooled, pH was made 6.0 (by addition NH4OH). The suspension obtained was centrifuged, washed with water and the mixture of chlorohydroxyquinolines was dried. 

CHLOROIODOQUINE see CHR500 5-CHLORO-7-IODO-8-QUINOLINOL see CHR500... 

C9H5CIINO 5-chloro-7-iodo-8-quinolinol 130-26-7 25.00 1.8959 2 15923 C9H60S thianaphthene-3-carboxaldehyde 5381-20-4 25.00 1.2362 2... 

C9H6CINO 5-chloro-8-quinolinol 130-16-5 25.00 1 3100 2 15965 C9H7CIO trans-3-phenyt-2-propenoyl chloride 17082-09-6 45.00 1.1617 1... 

HX = 5-methyl-, 5,7-dibromo, or 5-nitro-8-quinolinol) and V0L20Me (HL = 5-chloro-8-quinolinol) are among a series whose polarographic properties have been investigated. As the ligands diminish in donor power, the oxidized state of metal is preferentially stabilized. 

Chloro-7-iodo-8-quinolinol lodochlorhydroxyquin CgHjCIINO 130-26-7 306.499 ye br nd (al) 178.6 si FtOH s HOAc... 

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