2- chloro-4-nitrobenzamide

SYNS AKLOMIX 2-CHLORO-4-NITROBENZAMIDE SAFETY PROFILE When heated to decomposition emits toxic fumes of Cl" and NO.. 

Brown, Mueller, and Morehouse reported studies with 2-chloro-4-nitrobenzamide (XIV) and combinations of XIV with N-(p-nitro-phenyl)-4-acetamidobenzenesulfonamide (XV) against coccidiosis. These authors noted that tolerated levels of XIV were able to protect chickens from mortality due to exposure to E. necatrix or E. tenella, but that protection against E. acervulina could be achTeved only at toxic levels with XIV alone. A combination equivalent to a final dietary concentration of 0.025% of XIV and 0.020% of XV, designated Novastat prevented development of coccidiosis when tested against all three Eimeria species E. tenella,... 

Chloro-4-nitrobenzamide [3011-89-0] M 200.6, m 170-171", 172. Crystallise the amide from EtOH. [Jensen Ploug Acta Chem Acta 3 15 1949, Beilstein 9 H 404,9 III 1768.]... 

To a solution of 4-bromo-2-fluorobenzylamine and triethylamine in chloroform was added dropwise a solution of 4-chloro-2-nitrobenzoyl chloride in chloroform at 0°C with stirring and the mixture was stirred at the same temperature for 1 h. The reaction mixture was washed in turn with diluted aqueous hydrochloric acid and water, and then dried. Evaporation of the solvent followed by recrystallization from diethyl ether gave N-(4-bromo-2-fluorobenzyl)-4-chloro-2-nitrobenzamide. 

A mixture of N-(4-bromo-2-fluorobenzyl)-4-chloro-2-nitrobenzamide and iron (1.45 g) in acetic acid (66 ml) was stirred at 100°C for 30 min. After cooling, iron was filtered off. The filtrate was evaporated to give a residue, which was made alkaline with aqueous 1 N sodium hydroxide and extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide. 

Oxyfluorfen is weakly toxic to mammals. Acute oral ld,o for rats is 5000 mg/kg. Acute dermal lDjq for albino rats is 10000 mg/kg (Biroli et al., 1980). Fomesafen (code number PP 021) is a new diphenylether herbicide which was invented at the Id s Jealott s Hill Research Station, Its chemical name is 5-(2-chloro-4-tri-fluoromethyl)phenoxy-N-(methylsulfonyl)-2-nitrobenzamide (fomesafen. Flex ) (6). 

In a transition metal-free, one-pot, and regioselective process, 2-halo-benzenethiols 195 or 3-chloro-5-(trifluoromethyl)pyridine-2-thiol 196 reacted with N-substituted nitrobenzamides 197 to afford a library of dibenzo[I>,/][l,4]thiazepin-ll(10id)-ones 198 or pyridobenzothiazepines 199, respectively, via a Smiles rearrangement (13ACO130). 

Fe-filings added portionwise during 1.5 hrs. to a stirred refluxing soln. of 2.0 g. N-(2-benzoyl-4-chlorophenyl)-N-methyl-2-nitrobenzamide and NH4CI in2-meth-oxyethanol-water, and refluxing continued 1.5 hrs. 1.2 g. 2-chloro-5,6-di-hydro-5-methyl-6-oxo-12-phenyldibenzo[b,f] [l,5]diazocine. J. G. Topliss, E. P. Shapiro, and R. I. Taber, J. Med. Chem. 10, 642 (1967). 

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