Chloro-3-methylphenol

Stability volatile with water vapour may become slightly discoloured when exposed to air, light, moisture or heat, stable over a wide pH range from 1 to 14 

LC50 inhalation (dust, 4 h) 704mg/m air for rats (the concentration caused no deaths) 

Not irritant on the rabbit skin (exposure 4 h), however corrosive to rabbit eyes. In the guinea pig test PCMC acts  

The formation of stochiometric amounts of chloride ions demonstrated the complete mineralisation of the product.  

PCMC is most effective between pH 4 and 8, where, in fact, contrary to other phenol derivatives only PCMC is sufficiently water soluble. By comparing the microbicidal concentrations of PCMC with those of PCMC-Na (7.3.1a.), solutions of which have pH values higher than 8, one notices a distinctive decrease in the activity of PCMC in alkaline media (Table 61). 

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A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50 ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the residue Is washed with water and then extracted with benzene. The dried extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphen-oxy)-2-propanol. Treatment of the free base in benzene solution with dry hydrogen chloride yields the hydrochloride salt. 

Preparations of Resins. Most of the Novolak resins studied were prepared in sealed tubes, following the known procedures (24). Comparisons were made on samples prepared in this way. However, the 2-chloro-5-methylphenol-formaldehyde Novolak resin was made for more comprehensive studies in the following manner. The warm, preformed mixture of 107 g of 2-chloro-5-methylphenol and 40.5 g of trioxane was added dropwise to a mixture of 107 g of the phenol and 4.9 g of concentrated sulfuric acid (96% assay) at 125 to 130°C in a nitrogen atmosphere. The thickening mixture was then heated to 160 to 170°C, and finally the mixture was placed under vacuum at 180°C for 30 min. The reaction is as follows ... 

The UV-absorption spectra of these Novolak resins vary widely depending upon substitution. However, the m-cresol-benzaldehyde Novolak resin is characteristic in its transparency within 300-320 nm in comparison with the cresol-formaldehyde resin. The chlorinated Novolak resin made of 2-chloro-5-methylphenol and formaldehyde has a slightly stronger UV absorption in this wavelength range, but weaker absorption in the range of 250 and 300 nm in comparison with a commercially available cresol-formaldehyde Novolak resin, as shown in Figure 4. 

C7H6N2S 1,3-dihydro-2H-benzimidazole-2-thione 583-39-1 25.00 1.2590 2 10518 C7H7CIO 2-chloro-5-methylphenol 615-74-7 15.00 1.2150 1... 

Chloro-5-methylphenol 2-Chloro-5 -methylphenol 2-ChlorO 4-nitrophenol 6> Chlorophenol o-Chlorophenol o-Chlorophenol 6>-Chlorophenol m-Chlorophenol p-Chlorophenol / -Chlorophenol m-Cresol... 

Chloro-5-methylphenol 6-Chloro-m-cresol C7H7CIO 615-74-7 142.583 pr(peth) 46(3) 198(8) 1.215 vs H,0, EtOH... 

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