2-Chloro-6-isobutyl-3-methylpyrazine

In a similar manner, 3-isobutyl-6-methyl-3,6-dihydro-2,5(l//,4//)-pyrazinedione (9, R = Me) gave 2-chloro-3-isobutyl-6-methylpyrazine (10, R = Me), 2-chloro-6-isobutyl-3-methylpyrazine (11, R = Me), and 2,5-dichloro-3-isobutyl-6-methylpyrazine (12, R = Me) (27, 21, and 4%, respectively).295... 

Chloro-5,6-diethylpyrazine 1-oxide (219) (K2S2Os, H2S04, 20°C, 24 h 84%) 1250 2-chloro-3-isobutyl-6-methylpyrazine 1-oxide (220) (likewise 78%) 295 and 2-fluoropyrazine 1-oxide (likewise 40%).276... 

Chloro-3-isobutyl-6-isopropylpyrazine 1 -oxide 2-Chloro-3-isobutyl-6-isopropylpyrazine 4-oxide 2-Chloro-6-isobutyl-3-isopropylpyrazine 4-oxide 2-Chloro-3-isobutyl-6-methylpyrazine 2-Chloro-6-isobutyl-3-methylpyrazine 2-Chloro-3-isobutyl-6-methylpyrazine... 

Chloro-3-methylpyrazine (101,535) and 2-chloro-5-phenylpyrazine (363, 365a, 377, 824, 825) have been prepared from the corresponding hydroxy compound and phosphoryl chloride, 2-chloro-6-methylpyrazine from 2-hydroxy-6-methylpyrazine and phosphoryl chloride with one drop of dimethylformamide (681), and 2-benzyl(or s-butyl, isobutyl, or isopropyl)-3phosphoryl chloride with a trace of concentrated sulfuric acid (80). 2-Chloro-6-methyl-3-propyl- (826), 3[Pg.99]

Methoxypyrazines (31) have been prepared by diazomethane methylation of 2-hydroxy-3-isobutylpyrazine (60, 311, 367), 2-hydroxy-3-isopropylpyrazine (59, 367), 2-hydroxy-3-propyl(ethyl or hexyl)pyrazine (367), 3-hydroxy-2-isobutyl-5(and 6)methylpyrazine and 2-hydroxy-3-isobutyl-5,6-dimethylpyrazine (368), 2,3-dihydroxypyrazine (832), 2-hydroxy-5-methoxy- and 2,5-dihydroxy-3,6-diphenyl-pyrazine (832), 2-hydroxy-6-methoxy(and benzyloxy)pyrazine (832), 2,6-dihydroxy-3,5-diphenylpyrazine (873), 2,3,5-trifluoro-6-hydroxypyrazine (851), 2-chloro-6-hydroxy-3,5-diphenylpyrazine (873), 2-chloro-6-hydroxy-5-methyl-3-phenylpyrazine (873), 2-chloro-6-hydroxy-3-methyl-5-phenylpyrazine (873), 5,6-dichloro-1 -cyclohexyl-34iydroxy-2-oxo-l, 2-dihydropyrazine (853), 2-chloro-5-hydroxy-3-methoxy-6-methoxycarbonylpyrazine (881), 2-(4 -amino-3, 5 -dibromo-phenylsulfonamido)-3Tiydroxy-6-methoxypyrazine (881), 2-amino-3-hydroxy-... 

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