2-Chloro-5-ethoxy-3,6-dimethylpyrazine

Other alkoxy dechlorinations were 2-chloro-5-ethoxy-3,6-dimethylpyrazine (872) and 2-amino-6-chloro-3,5-dicyanopyrazine (484) with ethoxide ion 5-chloro-... 

Reactions of C-alkoxypyrazine A-oxides with phosphoryl chloride have been described in Section V.IG (756, 817, 838, 872, 881). For example, 3-ethoxy-2,5-dimethylpyrazine 1-oxide refluxed with phosphoryl chloride for 10 minutes gave 2-chloro-5-ethoxy-3,6-dimethylpyrazine and 2-chloromethyl-3-ethoxy-5-methyl-pyrazine (872). 

Dimethoxy(or diethoxy)-3,6-dimethylpyrazine 1,4-dioxide with phosphoryl chloride have been shown to give 2,5-bis(chloromethyl)-3,6-dimethoxy(or diethoxy)-pyrazine (756), 3-ethoxy-2,5-dimethylpyrazine 1-oxide gave 2-chloro-5-ethoxy-... 

Dicyano-3,6-dimethylpyrazine shaken with sodium ethoxide at room temperature gave 2-cyano-5-ethoxy-3,6-dimethylpyrazine and 2-cyano-5-hydroxy-3,6-dimethylpyrazine (288). Reactions of 2-chloro-6-cyanopyrazine with sodium methoxide have been described in Sections 1 A(2)(c). 

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