2-Chloro-5,6-diphenylpyrazine 1-oxide

Chloro-5,6-diphenyl-2-pyrazinecarbohydrazide 5-Chloro-3,6-diphenyl-2-pyrazinecarbonitrile 3-Chloro-5,6-diphenyl-2-pyrazinecarboxamide 2-Chloro-3,5-diphenylpyrazine 1 -oxide 2-Chloro-3,6-diphenylpyrazine 1-oxide 2-Chloro-3,6-diphenylpyrazine 4-oxide 2-Chloro-5,6-diphenylpyrazine 1-oxide... 

Chloro-3,5-diphenylpyrazine 1-oxide (266) gave 2-acetoxy-6-chloro-3, 5-diphenylpyrazine (267) (neat Ac20, reflux, 1 h 81%).1307... 

Chloro-3-isopropyl-5,6-dimethylpyrazine 2-Chloro-3-isopropyl-5,6-diphenylpyrazine 2-Chloro-3-isopropyl-5-methylpyrazine 2-Chloro-3-isopropyl-6-methylpyrazine 2-Chloro-6-isopropyl-3-methylpyrazine 2-Chloro-3-isopropyl-6-methylpyrazine 1 -oxide 2-Chloro-6-isopropyl-3-methylpyrazine 1-oxide 2-Chloro-3-isopropylpyrazine... 

The reactions of phosphoryl chloride and some hydroxypyrazine A-oxides with an unsubstituted position adjacent to the A-oxide function to give chlorohydroxy-pyrazines have been described in Section V.IG. In this way 3-hydroxy-2,5-diisobutylpyrazine 1-oxide was converted to 2-chloro-5-hydroxy-3,6-diisobutyl-pyrazine (101) and 2-hydroxy-3,5-diphenylpyrazine 1-oxide gave 2-chloro-6-hydroxy-3,5-diphenylpyrazine (873). 

Chloro-3,6-dipropylpyrazine 1-oxide 2-Chloro-5-ethoxy-3,6-dimethylpyr azine 2-Chloro-5-ethoxy-3,6-diphenylpyrazine 5-Chloro-6-ethoxy-3-guanidinocarbonyl-... 

---