Photosensitizers chlorin-based

Ando et al. 292,293 sported a series of chlorin dimers 341 and trimers 342 joined by amide bonds and found that among such oligomers, dimer 341 (Scheme 71) did show good tumor uptake and selectivity compared with the hematoporphyrin derivative (HpD). As part of their effort to improve the in vivo antitumor activity of chlorin-based photosensitizers, Pandey et extended this approach for the preparation of a series of amide-linked symmetrical and unsynunetrical chlorin dimers 345-347 (Scheme 72). For the preparation of unsymmeuical dimo 349, methyl pheophorfoide a was reacted with 1,3-propanediamine and the intermediate amide 345 was isolated in 80% yield. Reaction of 348 with H2(HPPH) afforded the unsymme-ttical dimer in 70% yield, and was found to be effective in... 

In the conventional applications of photodynamic therapy (PDT), fight-activated chemicals (photosensitizers) are used to destroy fast-growing cells and tissues. The commonly used sensitizers are based upon porphyrin-like molecules, e.g., porphyrins, chlorins, bacteriocholins, and phthalocyanines. These substances collect in... 

Ultraflne hydrophilic PAAm-based nanogels incorporated with meta-tetra (hydroxyphenyl) chlorine (mTHPC) as a photosensitizer were prepared for photodynamic therapy. In the process, both AAm and A,A-methylene( w acrylamide) as a cross-linker were directly emulsified into hex-ane/aerosol OT, without water, which allowed for the preparation of tiny PAAm nanoparticles with a diameter of 2-3 nm. The presence of water in hexane/aerosol OT produced 20 nm diameter PAAm particles with a relatively broad size distribution. " ... 

Rg. 8 Enzyme-activatable theranostic complexes reported by Cho et a/, based on graphene oxide (GO). Hyaluronic acid (HA) is modified with the porphyrin photosensitiser chlorin e6 (Ce6) and loaded onto graphene oxide by non-covalent interactions Hvalur-onidase ( enzyme ) cleaves the surface-bound hyaluronic acid to switch the photosensiter on upon irradiation with light at 680 nm, as well as eliciting a photothermal response from GO. 

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