Chloride substitution, steric course

Table I The Steric Course of Substitution of Chloride In els-[Co en2 Cl2]+ and in its Chloride Ion Pair in Methanol at 35°C ...

The term SNi reaction was coined during mechanistic investigations into this transformation with the substrates shown in Figure 2.30. Using the R enantiomer as the substrate, it was possible to elucidate the steric course of the substitution. Upon reaction with thionyl chloride in... 

The catalyzed Diels-Alder reaction of nonauxiliary-controlled homodienophiles has received much less attention than the auxiliary-controlled one. Systematic studies of aluminum chloride catalyzed addition of acyclic dienes 2 to substituted cyclohexenones l4 and 7 s have been undertaken. The nature of the substituent exerts a strong influence on the steric course of the reaction addition of the diene taking place from the less hindered face of the dienophile, anti to the substituent. The effect is stronger for 5- than for 4-substituted cyclohexenones. For some adducts cisjtrans isomerization under these reaction conditions has been observed4,5. 

---