Alginate chitosan

Li Z, Ramay HR, Hauch KD et al (2005) Chitosan-alginate hybrid scaffolds for bone tissue engineering. Biomaterials 26 3919-3928... 

Alginate/ Polyvinylsulfate Glycol-Chitosan Quaternary/ Calcium Chloride Complex is formed between both alginate and polyvinylsulfate and chitosan alginate is the precasting polymer. 26... 

Chitosan, cross-linked chitosan alginate gels (in presence of calcium ions) starch egg white, soybean and whey proteins... 

Peniche et al. (2004) successfully encapsulated up to 65 % of shark liver oil (rich in polyunsaturated fatty acids) in chitosan/alginate capsules in order to mask the oil s unpleasant taste. Here again it was found that the chitosan coating allowed a greater degree of control of capsule permeability. The capsules could be degraded by enzymes such as lipase or pancreatin. They were initially resistant to the acid environment of the stomach, although after 4 hours under intestinal conditions (pH = 7.4) the capsule walls were finally disrupted. 

Zhang, F., Guo, J., Peng, X., Fi, Y. (2004) Preparation and release behaviour of carboxy-methylated chitosan/alginate microspheres encapsulating bovine serum albumin. Journal of Applied Polymer Science, 92, 878-882. 

Figure 1. Simplified protocol of chitosan/alginate or alginate/ chitosan complex coacervate capsule formation (adapted from 10,20,22). ...

Table III. Effect of buffer treatment and esterification of alginate on the mechanical stability of chitosan/alginate coacervate capsules3...

Anal, A. K., Bhopatkar, D., Tokura, S.,Tamura, H., and Stevens, W. F. (2003), Chitosan-alginate multilayer beads for gastric passage and controlled intestinal release of protein, Drug Dev. Ind. Pharm., 29,713-724. 

The advantage of complex coacervates is that high payloads can be obtained. Chitosan/alginate coacervates have been reported to encapsulate up to 87% shark liver oil, which is rich in omega-3 fatty acids (Peniche et al. 2004). Microspheres of carboxymethyl chitosan/alginate hardened with calcium chloride have been used for encapsulation of up to 80% bovine serum albumin (Zhang et al. 2004). 

Zhang L., Guo J., Peng X., and Jin, Y. (2004). Preparation and release behavior of earboxy-methylated chitosan/alginate mierospheres eneapsulating bovine serum albumin. J. Appl. Polym. Sci. 92, 878-882. 

Naturally occurring polymers Polysaccharides Dextran Chitosan Alginate Starch Hyaluronic acid... 

Controlled degradation of chitosan, alginates and carrageenans — Upgrading and utilization of carbohydrates such as chitosan, sodium aiginate, carrageenan, cellulose,... 

Implantation of chitosan-alginate scaffolds into female Sprague-Dawley rats and cell viability test Alkaline phosphate activity (ALP) and total protein content using commercially available kits... 

Yan XL, Khor E, Lim LY. Chitosan-alginate films prepared with chitosans of different molecular weights. J Biomed Mater Res 2001 58 358-365. 

Wang, L., Khor, E., Wee, A. and Lim, L. Y, Chitosan-alginate PEC membrane as a wound dressing assessment of incisional wound healing, /. Biomed. Mater. Res., Appl. Biomater., 63, 610, 2002. 

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