Chirality via Upper and Lower Rim Substitution Patterns

A more subtle way to generate a chiral calixarene is to create dissymmetry or asymmetry within the molecule itself One of the means for doing this with a calix[4]arene is to establish a substitution pattern of AABC or ABCD on the upper or lower rim, producing a compound that is inherently chiral in all possible conformations. Tabulations of the cone, partial cone, 1,2-alternate, and 

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252e AABB CH,CO,MeCH,CO,MeCH,CO,H CH,CO,H SO,Ar S02Ar S02Ar S02Ar 1,2-alt 272 

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