Chirality phosphino compounds

Chiral phosphino(amines) based on amino-acid (215)460 t62 or partially hydrogenated binaphthyl (216)463 units have been prepared from Ph2PCl, the amine precursor (in the case of (215) from readily available amino ester hydrochlorides) and triethylamine as base. These compounds can be isolated as (off) white solids or oils in yields of up to 90%. 

Only a few reactions with bidentate ligands have been described. 32, reacting with the chiral carbohydrate derivative phenyl-4,6-o-(R)-benzylidene -2,3, 0-bis(diphenyl-phosphino-/ -D-glucopyranoside) (Ph-/ -glup), gave the compound [TcBr(CO)3 (Ph-/Tglup)] (56) in 53% yield. The complex was characterized by elemental analysis and i.r. spectroscopy [71]. Furthermore, reaction with dithio-... 

The preparation of chiral compounds by catalytic asymmetric hydrogenation is now well established. This year has again seen several reports on both the synthesis of and mechanistic studies on such systems, optical yields of 90% being achieved with a variety of catalysts. One such system which is worthy of note is the rhodium complex of the extremely simple chiral ligand (i )-l,2-bis(diphenyl-phosphino)propane [(i )-prophos] (7). This system is an efficient hydro-... 

---