Trisoxazolines chiral

Chiral trisoxazolines in asymmetric catalysis and molecular recognition 05CSR664. 

Oxazolines are nowadays essential ligands in asymmetric catalysis and also important synthons for stereoselective synthesis [8]. The success of the Cj-symmetric bis(oxazolines) ( BOX ) and pyridine-bis(oxazolines) ( Pybox ) discovered in the early 1990s has established them as a privileged class of ligands [9]. In contrast, the development and application of trisoxazolines lagged behind for a long time. Katsuki and collaborators [10] reported the first example of a chiral trisoxazoline in 1995 and their use in the allylic oxidation of alkenes (Kharasch-Sosnovsky reaction), as well as the enantioselective addition of diethylzinc to aldehydes. 

Trisox as a Bidentate Ligand Chiral Trisoxazolines in Copper(ll) Lewis Acid Catalysis and Palladium-Catalyzed Asymmetric Allylic Substitutions... 

Pseudo-C3-symmetrical trisoxazoline copper(II) complexes prove to be excellent catalysts in the Friedel-Crafts alkylation of indoles with alkylidene malonates (Eq. 7.13). Water tolerance of chiral catalyst trisoxazoline/Cu(OTf)2 was examined, and it was found that the addition of up to 200 equivalents of water relative to the catalyst in /,vo-butyl... 

Scheme 15.1 Modular assembly of trisoxazoline ligands by reaction of the metal-lated bisoxazolines with 2-bromooxazoline derivatives. This allows the synthesis of Cj-chiral ligands (A), the inversion of one...

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